Background

As skin ages, loss of connective tissue and a reduction in the amount of hyaluronic acids polymers can occur. Because platelet-rich plasma (PRP) is a source of growth factors and cytokines, it is believed that it might be involved in the activation of fibroblasts as well as the expression of type I collagen of human fibroblasts.

Objectives

This study was designed to determine the effectiveness of autologous PRP injections to aid in skin rejuvenation in the face, as assessed by biometric evaluations of instrumental tests as well as patient-reported results.

Methods and Patients

Patients filled out the informed consent forms. EmCyte Pure PRP (r) system was utilized to create neutrophil-deficient pure PRP in NJ. The effectiveness of the procedure was determined by biometrics and also a patient's result by a self-assessment survey at every visit, and after a 6-month follow-up.

Results

Eleven participants were part of the study. They received three PurePRP (r) treatments. A significant reduction in brown spot count and areas was observed after three months. The volume and count of wrinkles were reduced significantly. The parameters of skin firmness were significantly improved.

Redness on the skin significantly decreased after 169 days post-treatment on both the nasal as well as malar regions. A reduction of SLEB thickness was evident two months after the first injection. This was followed by the increase of SLEB thickness but without any effect on the thickness of subcutaneous fat. The self-assessment of the 6-month follow-up showed an average satisfaction of over 90%.

Conclusions

A series of three PurePRP treatments at a six-month follow-up led to significant skin rejuvenation in accordance with biometric parameters and was confirmed by self-assessment of the patient score.